TAS2R60

Entrez Summary: N/A
UniProt Summary: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Phenformin 20μM R05 exp212	-2.16
Chlorpromazine 10μM R07 exp344	-2.11
THZ1 0.06μM R08 exp531	-2.09
Lead acetate 2000μM R08 exp498 no dilution day6	-2.01
GSK2606414 1μM R05 exp236	-1.92
Geldanamycin 0.01μM R05 exp235	-1.85
Pyridostatin 4μM R05 exp240	-1.85
Rifampicin 1μM R00 exp31	-1.81
TGF-beta1 44ng/ml R08 exp528	-1.76
Golgicide-A 4μM R03 exp122	-1.7
RS-1 10μM R08 exp519	1.73

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

bitter taste receptor activity
detection of chemical stimulus involved in sensory perception of bitter taste
sensory perception of bitter taste
detection of chemical stimulus involved in sensory perception of taste
sensory perception of taste
detection of chemical stimulus involved in sensory perception
detection of chemical stimulus
sensory perception of chemical stimulus
detection of stimulus involved in sensory perception
detection of stimulus
G protein-coupled receptor activity
sensory perception
G protein-coupled receptor signaling pathway
nervous system process
system process