TBC1D20

Gene Information

Official Symbol: TBC1D20
Official Name: TBC1 domain family member 20
Aliases and Previous Symbols: N/A
Entrez ID: 128637
UniProt: Q96BZ9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein that belongs to a family of GTPase activator proteins of Rab-like small GTPases. The encoded protein and its cognate GTPase, Rab1, bind the nonstructural protein 5A (NS5A) of the hepatitis C virus (HCV) to mediate viral replication. Depletion of this protein inhibits replication of the virus and HCV infection. Mutations in this gene are associated with Warburg micro syndrome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].
UniProt Summary: GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Oligomycin-A 20μM R00 exp26	-2.9
Cerivastatin 0.15μM R05 exp226	-2.25
Golgicide-A 2μM R03 exp121	-2.22
CFI-400945 25μM R08 exp469	-2.09
Dynasore 10μM R04 exp180	-2.02
Fluvastatin 2.2μM R06 exp282	-1.94
Golgicide-A 4μM R03 exp122	-1.93
SB743921 0.001μM R05 exp244	-1.93
UMK57 0.6μM R03 exp107	-1.87
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.76
THZ1 0.06μM R08 exp531	-1.76
TIC10 10μM R08 exp532	1.72
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.75

Global Fraction of Cell Lines Where Essential: 5/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	1/75
lymphocyte	1/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8447
Expression level (log2 read counts): 6.05

Expression Distribution

positive regulation of ER to Golgi vesicle-mediated transport
positive regulation by virus of viral protein levels in host cell
lens fiber cell morphogenesis
positive regulation by host of viral genome replication
regulation by virus of viral protein levels in host cell
seminiferous tubule development
COPII-coated vesicle cargo loading
lens fiber cell development
modulation by host of viral genome replication
regulation of ER to Golgi vesicle-mediated transport
positive regulation by host of viral process
acrosome assembly
lipid droplet organization
lens morphogenesis in camera-type eye
vesicle cargo loading
lens fiber cell differentiation
modulation by host of viral process
secretory granule organization
positive regulation of viral genome replication
virion assembly
positive regulation of viral life cycle
COPII vesicle coating
integral component of Golgi membrane
vesicle targeting, rough ER to cis-Golgi
vesicle coating
COPII-coated vesicle budding
vesicle targeting, to, from or within Golgi
endoplasmic reticulum-Golgi intermediate compartment membrane
modification by host of symbiont morphology or physiology
interaction with symbiont
lens development in camera-type eye
Golgi vesicle budding
regulation of cilium assembly
localization within membrane
vesicle targeting
regulation of viral genome replication
vesicle budding from membrane
cellular component assembly involved in morphogenesis
positive regulation of viral process
modification of morphology or physiology of other organism involved in symbiotic interaction