TCEB1

Gene Information

Official Symbol: ELOC
Official Name: elongin C
Aliases and Previous Symbols: N/A
Entrez ID: 6921
UniProt: Q15369
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7821821). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity). {ECO:0000250|UniProtKB:P83940, ECO:0000269|PubMed:7821821}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 9/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/25
breast	1/33
central nervous system	1/56
cervix	1/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/14
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1725
Expression level (log2 read counts): 5.77

Expression Distribution

Screen	Score
FTY720 3μM R08 exp483	1.83
YM155 0.001μM R08 exp432	1.86
THZ531 0.11μM R07 exp409	2.06

elongin complex
positive regulation of transcription elongation from RNA polymerase II promoter
regulation of transcription elongation from RNA polymerase II promoter
positive regulation of DNA-templated transcription, elongation
regulation of DNA-templated transcription, elongation
transcription elongation from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter in response to hypoxia
DNA-templated transcription, elongation
regulation of transcription from RNA polymerase II promoter in response to stress
regulation of DNA-templated transcription in response to stress
cellular response to hypoxia
cellular response to decreased oxygen levels
cellular response to oxygen levels
ubiquitin-protein transferase activity
response to hypoxia
response to decreased oxygen levels
post-translational protein modification
response to oxygen levels
transcription by RNA polymerase II
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
protein catabolic process
protein ubiquitination
viral process
protein modification by small protein conjugation
symbiotic process
interspecies interaction between organisms
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
macromolecule catabolic process
organonitrogen compound catabolic process
nucleobase-containing compound biosynthetic process
response to abiotic stimulus
heterocycle biosynthetic process