THOP1

Entrez Summary: N/A
UniProt Summary: Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Apcin 25μM plus proTAME 2μM R04 exp177	-2.29
NN-Diethyl-meta-toluamide 500μM R08 exp438	1.92
Trichostatin-A 0.06μM R07 exp415	1.96
Latrunculin-B 10μM R07 exp374	2.04

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

peptide binding
mitochondrial intermembrane space
metalloendopeptidase activity
protein polyubiquitination
peptide metabolic process
protein ubiquitination
protein modification by small protein conjugation
cellular amide metabolic process
protein modification by small protein conjugation or removal
proteolysis