TIGIT

Entrez Summary: N/A
UniProt Summary: Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. {ECO:0000269|PubMed:19011627}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-1.98
Pimelic-diphenylamide-106 0.5μM R00 exp27	1.7

negative regulation of interleukin-12 production
positive regulation of interleukin-10 production
regulation of interleukin-10 production
regulation of interleukin-12 production
negative regulation of T cell activation
negative regulation of leukocyte cell-cell adhesion
negative regulation of lymphocyte activation
negative regulation of leukocyte activation
negative regulation of cell-cell adhesion
negative regulation of cell activation
negative regulation of cell adhesion
negative regulation of cytokine production
regulation of leukocyte cell-cell adhesion
regulation of T cell activation
signaling receptor binding
regulation of cell-cell adhesion
negative regulation of immune system process
positive regulation of cytokine production
regulation of lymphocyte activation
regulation of leukocyte activation
cell surface
regulation of cell activation
regulation of cell adhesion
regulation of cytokine production
identical protein binding
negative regulation of multicellular organismal process
regulation of immune system process
positive regulation of multicellular organismal process