TMEM133

Gene Information

Official Symbol: ARHGAP42
Official Name: Rho GTPase activating protein 42
Aliases and Previous Symbols: N/A
Entrez ID: 143872
UniProt: A6NI28
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May influence blood pressure by functioning as a GTPase- activating protein for RHOA in vascular smooth muscle. {ECO:0000269|PubMed:24335996}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Chloramphenicol 20μM R00 exp13	-1.88
SGC0946 7μM R03 exp151	-1.71
Olaparib 4μM R08 exp512	1.7
VER-155008 3.9μM R06 exp301	1.86
Epothilone-B 0.0015μM R05 exp231	1.96
Aphidicolin 0.4μM R08 exp440	2.03

Essentiality in NALM6

Essentiality Rank: 17013
Expression level (log2 read counts): 1.12

Expression Distribution

negative regulation of vascular smooth muscle contraction
negative regulation of vasoconstriction
regulation of vascular smooth muscle contraction
negative regulation of smooth muscle contraction
negative regulation of systemic arterial blood pressure
negative regulation of Rho protein signal transduction
negative regulation of muscle contraction
negative regulation of blood circulation
negative regulation of blood pressure
negative regulation of Ras protein signal transduction
positive regulation of blood vessel diameter
regulation of vasoconstriction
negative regulation of small GTPase mediated signal transduction
regulation of smooth muscle contraction
regulation of systemic arterial blood pressure
activation of GTPase activity
regulation of blood vessel diameter
regulation of tube diameter
regulation of tube size
regulation of Rho protein signal transduction
regulation of muscle contraction
vascular process in circulatory system
regulation of blood pressure
regulation of muscle system process
regulation of Ras protein signal transduction
GTPase activator activity
regulation of blood circulation
regulation of small GTPase mediated signal transduction
blood circulation
circulatory system process
positive regulation of GTPase activity
cellular component
regulation of GTPase activity
negative regulation of intracellular signal transduction
regulation of anatomical structure size
regulation of system process
positive regulation of hydrolase activity
negative regulation of multicellular organismal process
negative regulation of signal transduction
regulation of hydrolase activity