TMPRSS12

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Actinomycin-D 0.001μM R00 exp3	-2.21
Celastrol 0.12μM R05 exp225	-1.85
QNZ 0.01μM R05 exp241	-1.73
R-DABN 8μM R03 exp111	-1.73
Rapamycin 2μM R07 exp306	1.72
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	1.84
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	2.19

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Trypsin
DUF1986

serine-type endopeptidase activity
proteolysis