TNKS

Gene Information

Official Symbol: TNKS
Official Name: tankyrase
Aliases and Previous Symbols: N/A
Entrez ID: 8658
UniProt: O95271
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity. {ECO:0000269|PubMed:10988299, ECO:0000269|PubMed:11739745, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:21478859, ECO:0000269|PubMed:22864114, ECO:0000269|PubMed:23622245}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Alpha-Amanitin 0.5μM R00 exp5	-2.48
Rifampicin 1μM R00 exp31	-1.83
JQ1 0.8μM R08 exp435	-1.75
SB203580 25μM R03 exp149	-1.73
Ethambutol 25μM R08 exp481	-1.7
Nutlin-3A 1.6μM R06 exp294	-1.7
Thioridazine 5μM R08 exp530	1.86

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14248
Expression level (log2 read counts): 5.83

Expression Distribution

SAM 1
PARP
SAM 2
Ank 2
Ank

regulation of maintenance of mitotic sister chromatid cohesion, telomeric
negative regulation of telomeric DNA binding
negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric
negative regulation of maintenance of sister chromatid cohesion
negative regulation of maintenance of mitotic sister chromatid cohesion
regulation of telomeric DNA binding
negative regulation of sister chromatid cohesion
regulation of maintenance of mitotic sister chromatid cohesion
regulation of maintenance of sister chromatid cohesion
protein poly-ADP-ribosylation
protein auto-ADP-ribosylation
protein localization to chromosome, telomeric region
protein ADP-ribosylase activity
positive regulation of telomere capping
pericentriolar material
regulation of sister chromatid cohesion
regulation of telomere capping
negative regulation of telomere maintenance via telomere lengthening
mitotic spindle pole
NAD+ ADP-ribosyltransferase activity
negative regulation of mitotic sister chromatid segregation
protein ADP-ribosylation
negative regulation of sister chromatid segregation
negative regulation of chromosome segregation
positive regulation of telomere maintenance via telomerase
positive regulation of telomerase activity
positive regulation of telomere maintenance via telomere lengthening
negative regulation of telomere maintenance
negative regulation of mitotic nuclear division
negative regulation of nuclear division
positive regulation of telomere maintenance
chromosome, telomeric region
regulation of telomerase activity
regulation of telomere maintenance via telomerase
negative regulation of DNA binding
regulation of telomere maintenance via telomere lengthening
protein localization to chromosome
cellular response to nutrient
positive regulation of DNA biosynthetic process
regulation of mitotic sister chromatid segregation