TOB2

Gene Information

Official Symbol: TOB2
Official Name: transducer of ERBB2, 2
Aliases and Previous Symbols: N/A
Entrez ID: 10766
UniProt: Q14106
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pimelic-diphenylamide-106 5μM R00 exp28	-2.24
Phenformin 20μM R05 exp212	-1.94
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.83
Tenofovir 10μM R07 exp405	-1.75
Losmapimod 1μM R07 exp376	-1.71
SB203580 25μM R03 exp149	1.75
DKK1 89ng/ml R08 exp477	1.98

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11550
Expression level (log2 read counts): 6.04

Expression Distribution

vitamin D receptor binding
negative regulation of osteoclast differentiation
negative regulation of myeloid leukocyte differentiation
regulation of osteoclast differentiation
negative regulation of myeloid cell differentiation
positive regulation of ossification
negative regulation of leukocyte differentiation
regulation of myeloid leukocyte differentiation
female gamete generation
negative regulation of hemopoiesis
regulation of ossification
regulation of myeloid cell differentiation
transcription corepressor activity
regulation of leukocyte differentiation
negative regulation of immune system process
regulation of hemopoiesis
negative regulation of cell population proliferation
gamete generation
negative regulation of cell differentiation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
negative regulation of developmental process
multi-organism reproductive process
negative regulation of multicellular organismal process
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
reproductive process
reproduction
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
regulation of cell population proliferation
regulation of immune system process
positive regulation of multicellular organismal process
regulation of cell differentiation