TRIM24

Gene Information

Official Symbol: TRIM24
Official Name: tripartite motif containing 24
Aliases and Previous Symbols: N/A
Entrez ID: 8805
UniProt: O15164
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LB-100 2μM R05 exp210	-1.83
Benzoate 20000μM R08 exp456	-1.8
Rapamycin 10μM R00 exp30	-1.7
BML-284 0.09μM R08 exp460	2.01
UM131593 0.2μM R03 exp106	2.22

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2665
Expression level (log2 read counts): 6.02

Expression Distribution

PHD
zf-B box
Bromodomain

estrogen response element binding
perichromatin fibrils
regulation of vitamin D receptor signaling pathway
cellular response to estrogen stimulus
lysine-acetylated histone binding
nuclear receptor binding
regulation of response to extracellular stimulus
regulation of response to nutrient levels
nuclear euchromatin
methylated histone binding
p53 binding
response to estrogen
regulation of signal transduction by p53 class mediator
protein autophosphorylation
ubiquitin protein ligase activity
protein kinase activity
ubiquitin-protein transferase activity
transcription coactivator activity
regulation of protein stability
signaling receptor binding
chromatin binding
calcium ion homeostasis
transcription by RNA polymerase II
divalent inorganic cation homeostasis
metal ion homeostasis
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
negative regulation of cell population proliferation
protein catabolic process
protein ubiquitination
cation homeostasis
inorganic ion homeostasis
protein modification by small protein conjugation
ion homeostasis
zinc ion binding
protein phosphorylation
protein modification by small protein conjugation or removal
macromolecule catabolic process
organonitrogen compound catabolic process