TRIO

Entrez Summary: This gene encodes a large protein that functions as a GDP to GTP exchange factor. This protein promotes the reorganization of the actin cytoskeleton, thereby playing a role in cell migration and growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
UniProt Summary: Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:8643598, PubMed:27418539). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:8643598}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-1.94
proTAME 5μM R04 exp187	-1.82
ABT-702 5μM plus CoCl2 18μM R07 exp320	-1.81
Rapamycin 2μM plus FK-506 5μM R07 exp308	-1.81

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

transmembrane receptor protein tyrosine phosphatase signaling pathway
negative regulation of fat cell differentiation
Rho guanyl-nucleotide exchange factor activity
guanyl-nucleotide exchange factor activity
regulation of fat cell differentiation
regulation of Rho protein signal transduction
regulation of Ras protein signal transduction
axon guidance
neuron projection guidance
regulation of small GTPase mediated signal transduction
protein serine/threonine kinase activity
axonogenesis
axon development
cell morphogenesis involved in neuron differentiation
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cell part morphogenesis
chemotaxis
taxis
cell morphogenesis involved in differentiation
positive regulation of apoptotic process
positive regulation of programmed cell death
neuron projection development
positive regulation of cell death
negative regulation of cell differentiation
enzyme linked receptor protein signaling pathway
cell morphogenesis
neuron development
cellular component morphogenesis
negative regulation of developmental process
protein phosphorylation
central nervous system development
neuron differentiation
plasma membrane bounded cell projection organization
cell projection organization
phosphorylation
locomotion
G protein-coupled receptor signaling pathway
ATP binding