TUBGCP4

• Official Symbol: TUBGCP4
• Official Name: tubulin gamma complex associated protein 4
• Aliases and Previous Symbols: N/A
• Entrez ID: 27229
• UniProt: Q9UGJ1
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015].
• UniProt Summary: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 1619
• Expression level (log2 read counts): 7.07

Expression Distribution

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TUBGCP4 Expression in NALM6 Cells: 7.07