UBTF

Gene Information

Official Symbol: UBTF
Official Name: upstream binding transcription factor
Aliases and Previous Symbols: N/A
Entrez ID: 7343
UniProt: P17480
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011].
UniProt Summary: Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. {ECO:0000269|PubMed:28777933, ECO:0000269|PubMed:7982918}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cannabidiol 20μM R08 exp466	-2.18
Hippuristanol 0.12μM R08 exp488	-1.76
Pyridostatin 4μM R05 exp240	-1.71
BML-284 0.09μM R08 exp460	1.75
BRD2 inhibitor II 20μM R07 exp341	1.78
BN82002 4μM R07 exp340	1.85
Selumetinib 20μM R02 exp81	1.95

Global Fraction of Cell Lines Where Essential: 723/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	25/25
breast	32/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	15/15
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	14/14
ovary	25/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	14/15
prostate	1/1
skin	24/24
soft tissue	7/7
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 768
Expression level (log2 read counts): 8.29

Expression Distribution

RNA polymerase I upstream control element sequence-specific DNA binding
regulation of glucose mediated signaling pathway
RNA polymerase I CORE element sequence-specific DNA binding
RNA polymerase I preinitiation complex assembly
positive regulation of transcription by RNA polymerase I
transcription preinitiation complex assembly
transcription elongation from RNA polymerase I promoter
termination of RNA polymerase I transcription
regulation of transcription by RNA polymerase I
transcription initiation from RNA polymerase I promoter
transcription by RNA polymerase I
scaffold protein binding
DNA-templated transcription, termination
DNA-templated transcription, elongation
fibrillar center
protein-DNA complex assembly
DNA-templated transcription, initiation
protein-DNA complex subunit organization
chromatin binding
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
cellular protein-containing complex assembly
nucleolus
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
RNA binding
positive regulation of transcription, DNA-templated
protein-containing complex assembly
DNA-binding transcription factor activity, RNA polymerase II-specific
cellular nitrogen compound biosynthetic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
positive regulation of RNA metabolic process
macromolecule biosynthetic process
protein-containing complex subunit organization