UHMK1

Entrez Summary: The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

neuronal ribonucleoprotein granule
positive regulation of translational initiation
dendrite cytoplasm
ribonucleoprotein complex binding
regulation of protein export from nucleus
transferase activity
regulation of translational initiation
regulation of nucleocytoplasmic transport
positive regulation of translation
cell cycle arrest
positive regulation of cellular amide metabolic process
peptidyl-serine phosphorylation
protein autophosphorylation
peptidyl-serine modification
regulation of intracellular protein transport
axon
regulation of intracellular transport
regulation of translation
protein serine/threonine kinase activity
regulation of cellular amide metabolic process
posttranscriptional regulation of gene expression
regulation of cellular protein localization
negative regulation of cell cycle
neuron projection development
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
neuron development
peptidyl-amino acid modification
regulation of cellular localization
protein phosphorylation
Golgi apparatus
cell cycle process
neuron differentiation
regulation of protein localization
plasma membrane bounded cell projection organization
cell projection organization
regulation of cell cycle
phosphorylation
cell cycle