USP54

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-2.13
CI-1040 9.5μM R08 exp472	-1.95
Colchicine 0.009μM R05 exp215	-1.94
Benzoate 10000μM R08 exp455	-1.72
Bisphenol S 100μM R08 exp458	1.74
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	1.76
A-395 10μM R05 exp218	1.85
SNS-032 15μM R08 exp443	2.03

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

thiol-dependent ubiquitinyl hydrolase activity
protein deubiquitination
protein modification by small protein removal
protein modification by small protein conjugation or removal
proteolysis