VAX2

Entrez Summary: This gene encodes a homeobox protein and is almost exclusively expressed in the ventral portion of the retina during development. In mouse studies, this gene was found to be required for the correct formation of the optic fissure and other aspects of retinal development. [provided by RefSeq, Sep 2008].
UniProt Summary: Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

dorsal/ventral axis specification
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
ectoderm development
embryonic eye morphogenesis
chromatin DNA binding
dorsal/ventral pattern formation
axis specification
retina development in camera-type eye
eye morphogenesis
visual perception
sensory perception of light stimulus
DNA-binding transcription repressor activity, RNA polymerase II-specific
sensory organ morphogenesis
embryonic organ morphogenesis
camera-type eye development
regionalization
Wnt signaling pathway
cell-cell signaling by wnt
eye development
visual system development
sensory system development
axonogenesis
forebrain development
axon development
cell surface receptor signaling pathway involved in cell-cell signaling
cell morphogenesis involved in neuron differentiation
embryonic organ development
pattern specification process
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
RNA polymerase II proximal promoter sequence-specific DNA binding
cell part morphogenesis
sensory organ development
cell morphogenesis involved in differentiation
embryonic morphogenesis
neuron projection development
DNA-binding transcription factor activity
cell morphogenesis
brain development