WDR77

Gene Information

Official Symbol: WDR77
Official Name: WD repeat domain 77
Aliases and Previous Symbols: N/A
Entrez ID: 79084
UniProt: Q9BQA1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. {ECO:0000269|PubMed:11756452, ECO:0000269|PubMed:23071334}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-2.47
MS023 2μM R03 exp134	-2.21
VER-155008 3.9μM R06 exp301	-1.89
Docosahexaenoic-acid 50μM R07 exp356	-1.75
Vitamin-D3 40μM R08 exp536	1.8
Doxorubicin 0.02μM R08 exp478	1.96
CFI-400945 25μM R08 exp469	1.98
SNS-032 15μM R08 exp443	2
Aminopterin 0.005μM R07 exp335	2.06
Salinomycin 3.5μM R08 exp521	2.13
Ammonium tetrathiomolybdate 10μM R08 exp448	2.33
JQ1 0.8μM R08 exp435	3.48

Global Fraction of Cell Lines Where Essential: 674/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	24/28
blood	28/28
bone	25/25
breast	29/33
central nervous system	56/56
cervix	4/4
colorectal	16/17
esophagus	13/13
fibroblast	1/1
gastric	14/15
kidney	18/21
liver	20/20
lung	67/75
lymphocyte	14/14
ovary	23/26
pancreas	22/24
peripheral nervous system	15/16
plasma cell	15/15
prostate	0/1
skin	21/24
soft tissue	7/7
thyroid	2/2
upper aerodigestive	22/22
urinary tract	28/29
uterus	4/5

Essentiality in NALM6

Essentiality Rank: 431
Expression level (log2 read counts): 6.29

Expression Distribution

Gene	Correlation
SNAPC5	0.424
CD2BP2	0.416
PPP4C	0.414

secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
negative regulation of epithelial cell proliferation involved in prostate gland development
regulation of epithelial cell proliferation involved in prostate gland development
prostate glandular acinus development
methylosome
epithelial cell differentiation involved in prostate gland development
methyl-CpG binding
spliceosomal snRNP assembly
glandular epithelial cell differentiation
prostate gland development
negative regulation of reproductive process
nuclear receptor transcription coactivator activity
columnar/cuboidal epithelial cell differentiation
negative regulation of epithelial cell proliferation
regulation of reproductive process
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
urogenital system development
regulation of epithelial cell proliferation
RNA splicing
gland development
reproductive structure development
reproductive system development
ribonucleoprotein complex biogenesis
mRNA processing
developmental process involved in reproduction
negative regulation of cell population proliferation
epithelial cell differentiation
mRNA metabolic process
cellular protein-containing complex assembly
RNA processing
positive regulation of cell population proliferation
negative regulation of developmental process
Golgi apparatus
epithelium development
negative regulation of multicellular organismal process
reproductive process