WNT2
Gene Information
- Official Symbol: WNT2
- Official Name: Wnt family member 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 7472
- UniProt: P09544
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20018874). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). {ECO:0000250|UniProtKB:P21552, ECO:0000269|PubMed:20018874}.
Pfam Domains GO Terms
Pfam Domains
| wnt |
GO Terms
| lung induction |
| positive regulation of branching involved in lung morphogenesis |
| canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation |
| positive regulation of epithelial cell proliferation involved in lung morphogenesis |
| regulation of branching involved in lung morphogenesis |
| cell proliferation in midbrain |
| atrial cardiac muscle tissue morphogenesis |
| atrial cardiac muscle tissue development |
| regulation of epithelial cell proliferation involved in lung morphogenesis |
| extrinsic component of external side of plasma membrane |
| iris morphogenesis |
| Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation |
| Wnt signalosome |
| midbrain dopaminergic neuron differentiation |
| organ induction |
| labyrinthine layer blood vessel development |
| positive regulation of mesenchymal cell proliferation |
| positive regulation of cardiac muscle cell proliferation |
| developmental induction |
| cardiac epithelial to mesenchymal transition |
| cardiac atrium morphogenesis |
| dopaminergic neuron differentiation |
| placenta blood vessel development |
| regulation of mesenchymal cell proliferation |
| receptor ligand activity |
| positive regulation of cardiac muscle tissue growth |
| positive regulation of morphogenesis of an epithelium |
| cardiac atrium development |
| regulation of animal organ formation |
| positive regulation of heart growth |
| positive regulation of embryonic development |
| frizzled binding |
| regulation of cardiac muscle cell proliferation |
| positive regulation of cardiac muscle tissue development |
| labyrinthine layer development |
| positive regulation of organ growth |
| positive regulation of fibroblast proliferation |
| regulation of morphogenesis of a branching structure |
| mammary gland epithelium development |
| regulation of cardiac muscle tissue growth |
| regulation of heart growth |
| cardiac muscle tissue morphogenesis |
| positive regulation of muscle organ development |
| cellular response to retinoic acid |
| positive regulation of striated muscle tissue development |
| positive regulation of muscle tissue development |
| epithelial to mesenchymal transition |
| neural precursor cell proliferation |
| lens development in camera-type eye |
| regulation of cardiac muscle tissue development |
| muscle tissue morphogenesis |
| regulation of fibroblast proliferation |
| positive regulation of animal organ morphogenesis |
| midbrain development |
| muscle organ morphogenesis |
| embryonic placenta development |
| canonical Wnt signaling pathway |
| regulation of organ growth |
| positive regulation of endothelial cell proliferation |
| response to retinoic acid |
| camera-type eye morphogenesis |
| cardiac chamber morphogenesis |
| mammary gland development |
| regulation of embryonic development |
| regulation of endothelial cell proliferation |
| regulation of striated muscle tissue development |
| regulation of muscle tissue development |
| regulation of muscle organ development |
| eye morphogenesis |
| placenta development |
| cellular response to transforming growth factor beta stimulus |
| mesenchymal cell differentiation |
| response to transforming growth factor beta |
| cardiac muscle tissue development |
| lung development |
| cardiac chamber development |
| positive regulation of developmental growth |
| respiratory tube development |
| cytokine activity |
| central nervous system neuron differentiation |
| regulation of morphogenesis of an epithelium |
| positive regulation of epithelial cell proliferation |
| respiratory system development |
| cellular response to acid chemical |
| mesenchyme development |
| cell fate commitment |
| heart morphogenesis |
| sensory organ morphogenesis |
| regulation of animal organ morphogenesis |
| positive regulation of growth |
| positive regulation of DNA-binding transcription factor activity |
| striated muscle tissue development |
| muscle organ development |
| muscle tissue development |
| camera-type eye development |
| regulation of developmental growth |
| regulation of epithelial cell proliferation |
| response to acid chemical |
| Wnt signaling pathway |
| cell-cell signaling by wnt |
| eye development |
| visual system development |
| collagen-containing extracellular matrix |
| sensory system development |
| in utero embryonic development |
| gland development |
| reproductive structure development |
| regulation of DNA-binding transcription factor activity |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| reproductive system development |
| embryonic organ development |
| muscle structure development |
| blood vessel development |
| cellular response to growth factor stimulus |
| vasculature development |
| cardiovascular system development |
| cellular response to lipid |
| heart development |
| response to growth factor |
| sensory organ development |
| cell population proliferation |
| tissue morphogenesis |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| developmental process involved in reproduction |
| regulation of growth |
| brain development |
| head development |
| tube development |
| response to lipid |
| circulatory system development |
| positive regulation of cell population proliferation |
| animal organ morphogenesis |
| embryo development |
| central nervous system development |
| neuron differentiation |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| epithelium development |
| cell-cell signaling |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of developmental process |
| reproductive process |
| reproduction |
| response to endogenous stimulus |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| response to oxygen-containing compound |
| extracellular space |
| regulation of cell population proliferation |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Taxol 0.002μM R01 exp54 | -1.89 |
| Dynasore 7μM R08 exp436 | -1.88 |
| Vinblastine 0.002μM R01 exp60 | -1.82 |
| GSK-J4 1μM R07 exp362 | 1.7 |
| Palbociclib 1μM R07 exp382 | 1.79 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14409
- Expression level (log2 read counts): -7.68
Expression Distribution
WNT2 Expression in NALM6 Cells: -7.68
