ZBTB17

Gene Information

Official Symbol: ZBTB17
Official Name: zinc finger and BTB domain containing 17
Aliases and Previous Symbols: N/A
Entrez ID: 7709
UniProt: Q13105
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946). {ECO:0000269|PubMed:16142238, ECO:0000269|PubMed:19164764, ECO:0000269|PubMed:25245946, ECO:0000269|PubMed:9308237, ECO:0000269|PubMed:9312026}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UMK57 0.6μM R03 exp107	-1.95
Etoposide 1μM R00 exp19	-1.88
5-Fluorouracil 20μM R00 exp2	-1.86
UM0125461 0.74μM R02 exp84	1.79
Cerivastatin 0.15μM R05 exp226	1.88
5-Azacytidine 2μM R07 exp330	1.99
Thimerosal 0.85μM R08 exp529	1.99
ML-792 0.2μM R08 exp505	2.93

Global Fraction of Cell Lines Where Essential: 50/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	1/28
bone	3/26
breast	4/33
central nervous system	2/56
cervix	0/4
colorectal	1/17
esophagus	1/13
fibroblast	0/1
gastric	1/16
kidney	4/21
liver	0/20
lung	7/75
lymphocyte	1/16
ovary	1/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	1/1
skin	1/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	2/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 1555
Expression level (log2 read counts): 5.27

Expression Distribution

Gene	Correlation
GOLGA6L1	0.426
PIH1D1	0.414

zf-C2H2
BTB

core promoter binding
ectoderm development
transcription coactivator binding
gastrulation with mouth forming second
protein-DNA complex
IRE1-mediated unfolded protein response
positive regulation of cell cycle arrest
endoplasmic reticulum unfolded protein response
regulation of cell cycle arrest
cellular response to unfolded protein
cellular response to topologically incorrect protein
gastrulation
response to unfolded protein
response to topologically incorrect protein
response to endoplasmic reticulum stress
positive regulation of cell cycle process
transcription factor binding
positive regulation of cell cycle
DNA-binding transcription activator activity, RNA polymerase II-specific
RNA polymerase II proximal promoter sequence-specific DNA binding
embryonic morphogenesis
negative regulation of cell cycle
protein-containing complex
negative regulation of cell population proliferation
DNA-binding transcription factor activity
regulation of cell cycle process
embryo development
regulation of cell cycle
positive regulation of transcription by RNA polymerase II
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of cell population proliferation
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
cellular response to stress
positive regulation of RNA metabolic process
tissue development
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process