ZBTB7B
Gene Information
- Official Symbol: ZBTB7B
- Official Name: zinc finger and BTB domain containing 7B
- Aliases and Previous Symbols: N/A
- Entrez ID: 51043
- UniProt: O15156
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (By similarity). {ECO:0000250, ECO:0000269|PubMed:9370309}.
Pfam Domains GO Terms
Pfam Domains
| BTB |
GO Terms
| negative regulation of NK T cell proliferation |
| positive regulation of SREBP signaling pathway |
| NK T cell differentiation |
| negative regulation of CD8-positive, alpha-beta T cell differentiation |
| negative regulation of NK T cell activation |
| interleukin-17 secretion |
| regulation of SREBP signaling pathway |
| interleukin-17 production |
| regulation of NK T cell proliferation |
| regulation of CD8-positive, alpha-beta T cell differentiation |
| negative regulation of CD8-positive, alpha-beta T cell activation |
| negative regulation of T-helper 17 cell differentiation |
| regulation of NK T cell activation |
| negative regulation of T-helper 17 type immune response |
| negative regulation of alpha-beta T cell proliferation |
| positive regulation of brown fat cell differentiation |
| regulation of CD8-positive, alpha-beta T cell activation |
| regulation of brown fat cell differentiation |
| negative regulation of T-helper cell differentiation |
| regulation of transcription involved in cell fate commitment |
| regulation of T-helper 17 cell differentiation |
| positive regulation of histone deacetylation |
| adaptive thermogenesis |
| negative regulation of CD4-positive, alpha-beta T cell differentiation |
| ectoderm development |
| regulation of T-helper 17 type immune response |
| positive regulation of insulin receptor signaling pathway |
| positive regulation of protein deacetylation |
| positive regulation of cellular response to insulin stimulus |
| enhancer sequence-specific DNA binding |
| negative regulation of alpha-beta T cell differentiation |
| regulation of histone deacetylation |
| positive regulation of CD4-positive, alpha-beta T cell differentiation |
| negative regulation of CD4-positive, alpha-beta T cell activation |
| regulation of alpha-beta T cell proliferation |
| regulation of T-helper cell differentiation |
| positive regulation of CD4-positive, alpha-beta T cell activation |
| negative regulation of alpha-beta T cell activation |
| negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| negative regulation of T cell differentiation |
| regulation of protein deacetylation |
| negative regulation of adaptive immune response |
| lactation |
| positive regulation of alpha-beta T cell differentiation |
| regulation of CD4-positive, alpha-beta T cell differentiation |
| cytokine secretion |
| alpha-beta T cell differentiation |
| negative regulation of lymphocyte differentiation |
| negative regulation of T cell proliferation |
| positive regulation of alpha-beta T cell activation |
| regulation of CD4-positive, alpha-beta T cell activation |
| alpha-beta T cell activation |
| positive regulation of fat cell differentiation |
| regulation of alpha-beta T cell differentiation |
| regulation of insulin receptor signaling pathway |
| regulation of cellular response to insulin stimulus |
| body fluid secretion |
| negative regulation of mononuclear cell proliferation |
| negative regulation of lymphocyte proliferation |
| negative regulation of leukocyte proliferation |
| positive regulation of T cell differentiation |
| positive regulation of histone modification |
| regulation of alpha-beta T cell activation |
| positive regulation of lymphocyte differentiation |
| positive regulation of cold-induced thermogenesis |
| negative regulation of leukocyte differentiation |
| positive regulation of chromatin organization |
| negative regulation of T cell activation |
| histone deacetylase binding |
| negative regulation of immune effector process |
| negative regulation of leukocyte cell-cell adhesion |
| regulation of fat cell differentiation |
| mammary gland development |
| T cell differentiation |
| negative regulation of hemopoiesis |
| regulation of T cell differentiation |
| regulation of cold-induced thermogenesis |
| negative regulation of lymphocyte activation |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of histone modification |
| positive regulation of leukocyte differentiation |
| negative regulation of immune response |
| cytokine production |
| regulation of T cell proliferation |
| protein secretion |
| establishment of protein localization to extracellular region |
| regulation of adaptive immune response |
| protein localization to extracellular region |
| regulation of lymphocyte differentiation |
| peptide secretion |
| positive regulation of chromosome organization |
| negative regulation of leukocyte activation |
| negative regulation of cell-cell adhesion |
| positive regulation of hemopoiesis |
| regulation of chromatin organization |
| negative regulation of cell activation |
| positive regulation of T cell activation |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| positive regulation of leukocyte cell-cell adhesion |
| regulation of leukocyte proliferation |
| response to insulin |
| T cell activation |
| lymphocyte differentiation |
| cell fate commitment |
| positive regulation of cell-cell adhesion |
| regulation of leukocyte differentiation |
| negative regulation of cell adhesion |
| regulation of leukocyte cell-cell adhesion |
| regulation of T cell activation |
| leukocyte differentiation |
| regulation of chromosome organization |
| positive regulation of lymphocyte activation |
| lymphocyte activation |
| response to peptide hormone |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| positive regulation of leukocyte activation |
| gland development |
| positive regulation of cell activation |
| negative regulation of immune system process |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| regulation of hemopoiesis |
| regulation of immune effector process |
| response to peptide |
| transcription by RNA polymerase II |
| regulation of body fluid levels |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| regulation of lymphocyte activation |
| hemopoiesis |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| positive regulation of organelle organization |
| regulation of cell activation |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| immune system development |
| RNA biosynthetic process |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| negative regulation of cell differentiation |
| regulation of cellular response to stress |
| negative regulation of transcription by RNA polymerase II |
| protein homodimerization activity |
| response to hormone |
| leukocyte activation |
| negative regulation of developmental process |
| positive regulation of cell differentiation |
| response to organonitrogen compound |
| secretion by cell |
| export from cell |
| cell activation |
| response to nitrogen compound |
| nucleobase-containing compound biosynthetic process |
| secretion |
| regulation of immune response |
| positive regulation of immune system process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| regulation of organelle organization |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| protein transport |
| negative regulation of cellular biosynthetic process |
| peptide transport |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| amide transport |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| regulation of immune system process |
| RNA metabolic process |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| macromolecule biosynthetic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of protein modification process |
| nitrogen compound transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| IU1-47 25μM R04 exp182 | -1.73 |
| Aminopterin 0.005μM R07 exp335 | 1.88 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.521 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 1/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5588
- Expression level (log2 read counts): 2.0
Expression Distribution
ZBTB7B Expression in NALM6 Cells: 2.0
