ZYX

Entrez Summary: N/A
UniProt Summary: Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

stress fiber assembly
contractile actin filament bundle assembly
phagocytic vesicle
actin filament bundle assembly
actin filament bundle organization
stress fiber
integrin-mediated signaling pathway
transforming growth factor beta receptor signaling pathway
cell-cell adherens junction
actomyosin structure organization
cell-matrix adhesion
cellular response to transforming growth factor beta stimulus
response to transforming growth factor beta
cellular response to interferon-gamma
response to interferon-gamma
cell-substrate adhesion
transmembrane receptor protein serine/threonine kinase signaling pathway
actin filament organization
regulation of inflammatory response
focal adhesion
supramolecular fiber organization
actin cytoskeleton organization
cellular response to growth factor stimulus
response to growth factor
actin filament-based process
viral process
enzyme linked receptor protein signaling pathway
regulation of defense response
innate immune response
symbiotic process
interspecies interaction between organisms
cell adhesion
biological adhesion
defense response to other organism
cellular response to cytokine stimulus
regulation of response to external stimulus
response to cytokine
cytoskeleton organization
cell-cell signaling
cellular response to endogenous stimulus