UniProt Summary: May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development. {ECO:0000250|UniProtKB:Q8R2U2}.
Pfam DomainsGO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
positive regulation of Notch signaling pathway
regulation of Notch signaling pathway
negative regulation of neuron differentiation
negative regulation of neurogenesis
negative regulation of nervous system development
negative regulation of cell development
regulation of neuron differentiation
negative regulation of cell differentiation
regulation of neurogenesis
nucleolus
regulation of nervous system development
regulation of cell development
negative regulation of developmental process
negative regulation of multicellular organismal process
generation of neurons
neurogenesis
positive regulation of signal transduction
regulation of cell differentiation
positive regulation of cell communication
positive regulation of signaling
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)