DDRGK1
Gene Information
- Official Symbol: DDRGK1
- Official Name: DDRGK domain containing 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 65992
- UniProt: Q96HY6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Protein which interacts with the E3 UFM1-protein ligase UFL1 and one of its substrates TRIP4 and is required for TRIP4 ufmylation. Through TRIP4 ufmylation may regulate nuclear receptors-mediated transcription (PubMed:25219498). May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B (PubMed:23675531). May also play a role in the cellular response to endoplasmic reticulum stress (By similarity). {ECO:0000250|UniProtKB:Q80WW9, ECO:0000269|PubMed:23675531, ECO:0000269|PubMed:25219498}.
Pfam Domains GO Terms
Pfam Domains
| DDRGK |
GO Terms
| positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding |
| positive regulation of protein localization to endoplasmic reticulum |
| regulation of protein localization to endoplasmic reticulum |
| protein K69-linked ufmylation |
| protein polyufmylation |
| positive regulation of I-kappaB phosphorylation |
| regulation of I-kappaB phosphorylation |
| protein ufmylation |
| positive regulation of metallopeptidase activity |
| regulation of RNA polymerase II regulatory region sequence-specific DNA binding |
| regulation of metallopeptidase activity |
| ubiquitin-like protein ligase binding |
| positive regulation of transcription regulatory region DNA binding |
| negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
| RNA polymerase II repressing transcription factor binding |
| regulation of intracellular estrogen receptor signaling pathway |
| positive regulation of cell cycle G1/S phase transition |
| negative regulation of ubiquitin-dependent protein catabolic process |
| regulation of transcription regulatory region DNA binding |
| positive regulation of DNA binding |
| negative regulation of proteasomal protein catabolic process |
| negative regulation of proteolysis involved in cellular protein catabolic process |
| regulation of intracellular steroid hormone receptor signaling pathway |
| positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| negative regulation of cellular protein catabolic process |
| positive regulation of cell cycle phase transition |
| positive regulation of ubiquitin-dependent protein catabolic process |
| positive regulation of proteasomal protein catabolic process |
| positive regulation of proteolysis involved in cellular protein catabolic process |
| regulation of proteasomal ubiquitin-dependent protein catabolic process |
| regulation of DNA binding |
| negative regulation of protein catabolic process |
| positive regulation of cellular protein catabolic process |
| positive regulation of NF-kappaB transcription factor activity |
| regulation of ubiquitin-dependent protein catabolic process |
| regulation of cell cycle G1/S phase transition |
| cartilage development |
| positive regulation of binding |
| regulation of proteasomal protein catabolic process |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| positive regulation of peptidase activity |
| regulation of proteolysis involved in cellular protein catabolic process |
| positive regulation of protein catabolic process |
| connective tissue development |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| regulation of cellular protein catabolic process |
| negative regulation of cellular catabolic process |
| response to endoplasmic reticulum stress |
| positive regulation of DNA-binding transcription factor activity |
| positive regulation of cell cycle process |
| negative regulation of catabolic process |
| positive regulation of cellular protein localization |
| negative regulation of proteolysis |
| positive regulation of proteolysis |
| positive regulation of cellular catabolic process |
| regulation of binding |
| positive regulation of cell cycle |
| regulation of protein catabolic process |
| regulation of DNA-binding transcription factor activity |
| positive regulation of catabolic process |
| regulation of peptidase activity |
| regulation of cell cycle phase transition |
| skeletal system development |
| positive regulation of cell migration |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| regulation of cellular protein localization |
| positive regulation of locomotion |
| regulation of proteolysis |
| regulation of cell cycle process |
| positive regulation of hydrolase activity |
| protein modification by small protein conjugation |
| regulation of cellular catabolic process |
| regulation of cell migration |
| nucleolus |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| regulation of cellular localization |
| endoplasmic reticulum membrane |
| regulation of locomotion |
| protein modification by small protein conjugation or removal |
| regulation of cellular component movement |
| regulation of catabolic process |
| negative regulation of cell death |
| endoplasmic reticulum |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| positive regulation of phosphorylation |
| negative regulation of protein metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of cell cycle |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| regulation of cell death |
| cellular response to stress |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 2/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7384
- Expression level (log2 read counts): 5.46
Expression Distribution
DDRGK1 Expression in NALM6 Cells: 5.46
