UFL1

Gene Information

Official Symbol: UFL1
Official Name: UFM1 specific ligase 1
Aliases and Previous Symbols: N/A
Entrez ID: 23376
UniProt: O94874
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, a post-translational modification on lysine residues of proteins that may play a crucial role in a number of cellular processes. Mediates DDRGK1 ufmylation and may regulate the proteasomal degradation of DDRGK1 and CDK5RAP3 thereby modulating NF-kappa-B signaling (PubMed:20018847, PubMed:20164180, PubMed:20228063, PubMed:25219498). May also through TRIP4 ufmylation play a role in nuclear receptors-mediated transcription (PubMed:25219498). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). {ECO:0000269|PubMed:20018847, ECO:0000269|PubMed:20164180, ECO:0000269|PubMed:20228063, ECO:0000269|PubMed:23152784, ECO:0000269|PubMed:25219498}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.005μM R00 exp6	-2.17
Ethanol 0.01 R05 exp234	-2.16
Thapsigargin 0.005μM R07 exp407	-1.95
Golgicide-A 4μM R03 exp122	-1.94
Cyclosporin-A 0.8μM R07 exp347	-1.75
MS023 2μM R03 exp134	1.72
Trimetrexate 0.03μM R08 exp535	1.72
iCRT14 30μM R08 exp492	1.76
Mitomycin-C 0.06μM R08 exp503	1.76
QNZ 0.01μM R08 exp439	1.76
CCT251545 20μM R07 exp326	1.78
CI-1040 9.5μM R08 exp472	1.84
MS023 7μM R03 exp135	1.84
ML-792 0.2μM R08 exp505	1.88
Clomiphene 4.4μM R02 exp68	1.93
Erlotinib 10μM R05 exp216	1.97
Amiloride 100μM R08 exp447	1.98
BI-2536 0.0042μM R03 exp95	2.76

Global Fraction of Cell Lines Where Essential: 29/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	2/28
bone	0/26
breast	0/33
central nervous system	3/56
cervix	0/4
colorectal	2/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	2/21
liver	3/20
lung	1/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	5/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5012
Expression level (log2 read counts): 6.27

Expression Distribution

Gene	Correlation
UBA5	0.702
C1orf27	0.667
UFSP2	0.656
UFC1	0.606
UFM1	0.599
DDRGK1	0.512
UBE2J1	0.42
ALG6	0.416

UFM1 transferase activity
protein polyufmylation
protein K69-linked ufmylation
protein ufmylation
response to L-glutamate
positive regulation of glial cell proliferation
regulation of glial cell proliferation
regulation of intracellular estrogen receptor signaling pathway
positive regulation of gliogenesis
negative regulation of protein ubiquitination
regulation of intracellular steroid hormone receptor signaling pathway
negative regulation of NF-kappaB transcription factor activity
negative regulation of protein modification by small protein conjugation or removal
response to amino acid
regulation of gliogenesis
regulation of proteasomal ubiquitin-dependent protein catabolic process
osteoblast differentiation
regulation of ubiquitin-dependent protein catabolic process
negative regulation of DNA-binding transcription factor activity
regulation of proteasomal protein catabolic process
regulation of protein ubiquitination
response to nutrient
regulation of proteolysis involved in cellular protein catabolic process
regulation of protein modification by small protein conjugation or removal
regulation of cellular protein catabolic process
response to endoplasmic reticulum stress
ossification
neuron projection
response to acid chemical
regulation of protein catabolic process
regulation of DNA-binding transcription factor activity
positive regulation of neurogenesis
response to nutrient levels
response to extracellular stimulus
positive regulation of nervous system development
positive regulation of cell development
negative regulation of protein modification process
protein-containing complex
regulation of proteolysis
protein modification by small protein conjugation