EIF4G2

Entrez Summary: N/A
UniProt Summary: Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. {ECO:0000269|PubMed:11511540, ECO:0000269|PubMed:11943866, ECO:0000269|PubMed:9032289, ECO:0000269|PubMed:9049310}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hippuristanol 0.12μM R08 exp488	-2.3
Hippuristanol 0.12μM R08 exp489 no dilution day6	-2.24
Taxol 0.004μM R03 exp103	-2.09
Centrinone 0.5μM R07 exp343	-2.08
GSK461364A 0.005μM R03 exp125	-1.8
Nocodazole 0.2μM R00 exp24	-1.79
Tunicamycin 0.04μM R07 exp418	-1.71
Dimethyl-Sulfoxide 1pc R03 exp120	1.72
∆-9-Tetrahydrocannabinol 30μM R08 exp445	1.77
LY2090314 0.003μM R08 exp500 no dilution day6	1.78
CAY10603 0.55μM R08 exp467	1.81
Pyridostatin 4μM R05 exp240	1.97
LB-100 4.1μM R02 exp72	1.99
Radicicol 0.16μM R05 exp242	2
ML-792 0.2μM R08 exp505	2.09
Salinomycin 3.5μM R08 exp521	2.26
Lead acetate 2000μM R08 exp498 no dilution day6	2.55
Lead acetate 2000μM R08 exp497	2.65
Actinomycin-D 0.001μM R00 exp3	2.67
Bortezomib 0.005μM R00 exp6	2.73
Vincristine 0.0005μM R04 exp190	3.36

Gene	Correlation
PRRC2C	0.416

Global Fraction of Cell Lines Where Essential: 177/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	7/28
blood	15/28
bone	7/26
breast	14/33
central nervous system	10/56
cervix	0/4
colorectal	1/17
esophagus	2/13
fibroblast	0/1
gastric	4/16
kidney	5/21
liver	11/20
lung	17/75
lymphocyte	6/16
ovary	6/26
pancreas	0/24
peripheral nervous system	6/16
plasma cell	4/15
prostate	0/1
skin	5/24
soft tissue	3/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	4/29
uterus	2/5

Expression Distribution