IREB2
Gene Information
- Official Symbol: IREB2
- Official Name: iron responsive element binding protein 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 3658
- UniProt: P48200
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Aconitase |
| Aconitase C |
GO Terms
| iron-responsive element binding |
| aconitate hydratase activity |
| citrate metabolic process |
| protoporphyrinogen IX biosynthetic process |
| protoporphyrinogen IX metabolic process |
| translation repressor activity |
| tricarboxylic acid metabolic process |
| heme biosynthetic process |
| porphyrin-containing compound biosynthetic process |
| tetrapyrrole biosynthetic process |
| heme metabolic process |
| intestinal absorption |
| tricarboxylic acid cycle |
| porphyrin-containing compound metabolic process |
| 4 iron, 4 sulfur cluster binding |
| osteoclast differentiation |
| pigment biosynthetic process |
| tetrapyrrole metabolic process |
| cellular iron ion homeostasis |
| pigment metabolic process |
| iron ion transport |
| digestive system process |
| aerobic respiration |
| iron ion homeostasis |
| erythrocyte homeostasis |
| post-embryonic development |
| antibiotic metabolic process |
| cellular transition metal ion homeostasis |
| myeloid cell homeostasis |
| myeloid leukocyte differentiation |
| digestion |
| transition metal ion transport |
| negative regulation of translation |
| transition metal ion homeostasis |
| negative regulation of cellular amide metabolic process |
| cellular respiration |
| homeostasis of number of cells |
| cofactor biosynthetic process |
| myeloid cell differentiation |
| energy derivation by oxidation of organic compounds |
| leukocyte differentiation |
| regulation of translation |
| regulation of cellular amide metabolic process |
| generation of precursor metabolites and energy |
| cofactor metabolic process |
| drug metabolic process |
| posttranscriptional regulation of gene expression |
| hemopoiesis |
| cellular metal ion homeostasis |
| hematopoietic or lymphoid organ development |
| metal ion homeostasis |
| cellular cation homeostasis |
| metal ion transport |
| cellular ion homeostasis |
| immune system development |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| ion homeostasis |
| cation transport |
| cellular homeostasis |
| carboxylic acid metabolic process |
| oxidation-reduction process |
| oxoacid metabolic process |
| organic acid metabolic process |
| negative regulation of cellular protein metabolic process |
| negative regulation of protein metabolic process |
| chemical homeostasis |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| mitochondrion |
| organic cyclic compound biosynthetic process |
| ion transport |
| negative regulation of cellular macromolecule biosynthetic process |
| RNA binding |
| organonitrogen compound biosynthetic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| cellular nitrogen compound biosynthetic process |
| homeostatic process |
| negative regulation of gene expression |
| small molecule metabolic process |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 1/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 1/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16626
- Expression level (log2 read counts): 7.54
Expression Distribution
IREB2 Expression in NALM6 Cells: 7.54
