NAA10

Gene Information

Official Symbol: N/AA10
Official Name: N-alpha-acetyltransferase 10, NatA catalytic subunit
Aliases and Previous Symbols: N/A
Entrez ID: 8260
UniProt: P41227
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that functions as the catalytic subunit of the major amino-terminal acetyltransferase A complex. Mutations in this gene are the cause of Ogden syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].
UniProt Summary: Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity (PubMed:15496142, PubMed:19826488, PubMed:19420222, PubMed:20145209, PubMed:27708256, PubMed:25489052). Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). Acts as a negative regulator of sister chromatid cohesion during mitosis (PubMed:27422821). {ECO:0000269|PubMed:12464182, ECO:0000269|PubMed:15496142, ECO:0000269|PubMed:19420222, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20145209, ECO:0000269|PubMed:25489052, ECO:0000269|PubMed:27422821, ECO:0000269|PubMed:27708256}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dihydrosphingosine 8μM R08 exp476	-2.51
Diepoxybutane 3μM R07 exp354	-2.35
Etoposide 1μM R00 exp19	-2.24
NFN1 0.4μM R03 exp99	-2.03
BML-284 0.09μM R08 exp460	-1.93
Hydroxyurea 100μM R07 exp329	-1.88
Cytochalasin-B 5μM R07 exp349	-1.85
Mdivi-1 15μM R05 exp217	-1.84
Etoposide 10μM R00 exp20	-1.75
Quinacrine 2.5μM R03 exp146	-1.75
Doxorubicin 0.02μM R08 exp478	1.93

Global Fraction of Cell Lines Where Essential: 652/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	25/26
bone	26/26
breast	27/30
central nervous system	44/49
cervix	4/4
colorectal	17/17
esophagus	11/11
fibroblast	1/1
gastric	14/14
kidney	18/18
liver	16/19
lung	66/72
lymphocyte	15/16
ovary	24/25
pancreas	22/22
peripheral nervous system	15/15
plasma cell	12/12
prostate	1/1
skin	13/20
soft tissue	8/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	23/28
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 38
Expression level (log2 read counts): 5.98

Expression Distribution