PATZ1
Gene Information
- Official Symbol: PATZ1
- Official Name: POZ/BTB and AT hook containing zinc finger 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 23598
- UniProt: Q9HBE1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Transcriptional repressor. {ECO:0000269|PubMed:10713105}.
Pfam Domains GO Terms
Pfam Domains
| BTB |
GO Terms
| male gonad development |
| T cell differentiation |
| development of primary male sexual characteristics |
| male sex differentiation |
| gonad development |
| development of primary sexual characteristics |
| T cell activation |
| lymphocyte differentiation |
| sex differentiation |
| leukocyte differentiation |
| lymphocyte activation |
| chromatin binding |
| reproductive structure development |
| reproductive system development |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| spermatogenesis |
| hemopoiesis |
| male gamete generation |
| hematopoietic or lymphoid organ development |
| immune system development |
| developmental process involved in reproduction |
| gamete generation |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| leukocyte activation |
| multi-organism reproductive process |
| cell activation |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Rapamycin 1μM R00 exp29 | -1.85 |
| Rifampicin 1μM R00 exp31 | -1.75 |
| TRAIL 5ng/ml R00 exp35 | 1.73 |
| TRAIL 50ng/ml R00 exp36 | 1.74 |
| Phorbol-12-myristate-13-acetate 0.57μM R08 exp514 | 2.12 |
| A-196 10μM R03 exp114 | 2.43 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2623
- Expression level (log2 read counts): 6.37
Expression Distribution
PATZ1 Expression in NALM6 Cells: 6.37
