POLR1B
Gene Information
- Official Symbol: POLR1B
- Official Name: RNA polymerase I subunit B
- Aliases and Previous Symbols: N/A
- Entrez ID: 84172
- UniProt: Q9H9Y6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| RNA pol Rpb2 6 |
| RNA pol Rpb2 7 |
| RNA pol Rpb2 3 |
| RNA pol Rpb2 2 |
| RNA pol Rpb2 1 |
| RNA pol Rpa2 4 |
GO Terms
| nucleologenesis |
| ribonucleoside binding |
| nucleolus organization |
| RNA polymerase I complex |
| RNA polymerase I activity |
| rRNA transcription |
| transcription elongation from RNA polymerase I promoter |
| termination of RNA polymerase I transcription |
| DNA-directed 5-3 RNA polymerase activity |
| transcription initiation from RNA polymerase I promoter |
| embryo implantation |
| transcription by RNA polymerase I |
| positive regulation of gene expression, epigenetic |
| DNA-templated transcription, termination |
| DNA-templated transcription, elongation |
| ncRNA transcription |
| nucleus organization |
| female pregnancy |
| multi-multicellular organism process |
| DNA-templated transcription, initiation |
| regulation of gene expression, epigenetic |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| nucleolus |
| multi-organism reproductive process |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| organic cyclic compound biosynthetic process |
| reproductive process |
| reproduction |
| DNA binding |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| positive regulation of gene expression |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 568/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 0/1 |
| bile duct | 20/28 |
| blood | 19/28 |
| bone | 16/25 |
| breast | 22/33 |
| central nervous system | 51/56 |
| cervix | 4/4 |
| colorectal | 13/17 |
| esophagus | 12/13 |
| fibroblast | 1/1 |
| gastric | 14/15 |
| kidney | 15/21 |
| liver | 17/20 |
| lung | 60/75 |
| lymphocyte | 11/14 |
| ovary | 20/26 |
| pancreas | 17/24 |
| peripheral nervous system | 13/16 |
| plasma cell | 8/15 |
| prostate | 0/1 |
| skin | 19/24 |
| soft tissue | 5/7 |
| thyroid | 2/2 |
| upper aerodigestive | 20/22 |
| urinary tract | 26/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 115
- Expression level (log2 read counts): 6.9
Expression Distribution
POLR1B Expression in NALM6 Cells: 6.9
