RSF1

Entrez Summary: N/A
UniProt Summary: Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex (PubMed:12972596). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11944984, PubMed:11788598). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UM131593 0.1μM R01 exp58	-1.8
All-trans-Retinoic-Acid 8μM R07 exp333	1.71
GSK626616 14μM R08 exp485	1.74
Trimetrexate 0.03μM R08 exp535	1.77
Tunicamycin 0.04μM R07 exp418	1.86
Zebularine 20μM R07 exp423	1.87
All-trans-Retinoic-Acid 40μM R07 exp334	1.89
QNZ 0.01μM R05 exp241	1.89
Thapsigargin 0.005μM R07 exp407	1.96
Dexamethasone 0.006μM R07 exp351	2
EPZ-5676 30μM R05 exp233	2.04
I-BRD9 4μM R07 exp365	2.1
MK-1775 0.32μM R02 exp75	2.14
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	2.21
Rapamycin 10μM R00 exp30	2.35
Calcium Ionophore 0.4μM R07 exp342	2.41
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	2.41
LB-100 2μM R05 exp210	2.57

Gene	Correlation
HGC6.3	0.473
ZNF148	0.41

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution