UBA6
Gene Information
- Official Symbol: UBA6
- Official Name: ubiquitin like modifier activating enzyme 6
- Aliases and Previous Symbols: N/A
- Entrez ID: 55236
- UniProt: A0AVT1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| UBA e1 thiolCys |
| UBA e1 C |
| ThiF |
| UBACT |
GO Terms
| FAT10 activating enzyme activity |
| amygdala development |
| ubiquitin activating enzyme activity |
| dendritic spine development |
| hippocampus development |
| dendrite development |
| limbic system development |
| learning |
| pallium development |
| locomotory behavior |
| telencephalon development |
| learning or memory |
| cognition |
| forebrain development |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| behavior |
| proteolysis involved in cellular protein catabolic process |
| cellular protein catabolic process |
| neuron projection development |
| protein catabolic process |
| protein ubiquitination |
| brain development |
| protein modification by small protein conjugation |
| head development |
| neuron development |
| cellular macromolecule catabolic process |
| central nervous system development |
| protein modification by small protein conjugation or removal |
| neuron differentiation |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| proteolysis |
| nervous system process |
| ATP binding |
| generation of neurons |
| neurogenesis |
| cell development |
| organic substance catabolic process |
| cellular catabolic process |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| BIRC6 | 0.639 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 3/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 1/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 1/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6848
- Expression level (log2 read counts): 6.62
Expression Distribution
UBA6 Expression in NALM6 Cells: 6.62
