ZNF622
Gene Information
- Official Symbol: ZNF622
- Official Name: zinc finger protein 622
- Aliases and Previous Symbols: N/A
- Entrez ID: 90441
- UniProt: Q969S3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development.
Pfam Domains GO Terms
Pfam Domains
| zf-C2H2 jaz |
| zf-C2H2 2 |
GO Terms
| intrinsic apoptotic signaling pathway in response to oxidative stress |
| cell death in response to oxidative stress |
| preribosome, large subunit precursor |
| cytosolic large ribosomal subunit |
| ribosomal large subunit biogenesis |
| positive regulation of JNK cascade |
| intrinsic apoptotic signaling pathway |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| regulation of JNK cascade |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| cellular response to oxidative stress |
| apoptotic signaling pathway |
| ribosome biogenesis |
| response to oxidative stress |
| ribonucleoprotein complex biogenesis |
| positive regulation of MAPK cascade |
| positive regulation of kinase activity |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| positive regulation of transferase activity |
| positive regulation of cell death |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| zinc ion binding |
| nucleolus |
| regulation of kinase activity |
| apoptotic process |
| regulation of transferase activity |
| Golgi apparatus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| programmed cell death |
| positive regulation of phosphorylation |
| cell death |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of protein modification process |
| RNA binding |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| regulation of apoptotic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1322
- Expression level (log2 read counts): 4.77
Expression Distribution
ZNF622 Expression in NALM6 Cells: 4.77
