AK6
Gene Information
- Official Symbol: AK6
- Official Name: adenylate kinase 6
- Aliases and Previous Symbols: N/A
- Entrez ID: 102157402
- UniProt: Q9Y3D8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and dCMP are also good substrates. IMP is phosphorylated to a much lesser extent. All nucleoside triphosphates ATP, GTP, UTP, CTP, dATP, dCTP, dGTP, and TTP are accepted as phosphate donors. CTP is the best phosphate donor, followed by UTP, ATP, GTP and dCTP. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation. {ECO:0000269|PubMed:15630091}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 849
- Expression level (log2 read counts): 5.52
AK6 Expression in NALM6 Cells: 5.52
