C10orf12

Entrez Summary: LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]).[supplied by OMIM, Mar 2008].
UniProt Summary: May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand- dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR. {ECO:0000250, ECO:0000269|PubMed:12535528}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BH1 1μM R04 exp169	-2.2
NN-Diethyl-meta-toluamide 500μM R08 exp438	-1.9
Vemurafenib 6.6μM R02 exp89	-1.9
IL-3 9ng/ml R08 exp493	-1.77
CB-839 10μM R05 exp224	1.72
Nocodazole 0.2μM R00 exp24	1.81
Quercetin 20μM R08 exp517	1.84
BI-2536 0.0042μM R03 exp95	1.85
Epothilone-B 0.0015μM R05 exp231	1.86
MS094 2μM R03 exp136	1.89
Rotenone 20μM R00 exp34	1.92
LY2090314 0.003μM R08 exp500 no dilution day6	2.13
MLN-4924 0.2μM R00 exp21	2.15
Diepoxybutane 3μM R07 exp354	2.2
Fluvastatin 2.2μM R06 exp282	2.35
LY2090314 0.003μM R08 exp499	2.35
Hinokiflavone 12μM R08 exp487	2.38
THZ1 0.06μM R08 exp531	2.64
Doxorubicin 0.02μM R08 exp478	2.74
SNS-032 15μM R08 exp443	2.79

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution