C21orf91

Entrez Summary: N/A
UniProt Summary: Plays a role in cortical progenitor cell proliferation and differentiation. Promotes dendritic spine development of post- migratory cortical projection neurons by modulating the beta- catenin signaling pathway. {ECO:0000250|UniProtKB:Q9D7G4}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Demecolcine 0.03μM R05 exp228	-2.21
ABT-702 5μM R06 exp261	-1.97
3-Bromopyruvate 7μM R04 exp175	-1.9
Aphidicolin 0.4μM R08 exp440	-1.75
WNT3A 44ng/ml R08 exp537	-1.71
GSK2606414 1μM R05 exp236	2.02
Lead acetate 2000μM R08 exp498 no dilution day6	2.02
GSK461364A 0.1μM R03 exp126	2.21
Vemurafenib 6.6μM R08 exp434	2.21
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	2.25
MS023 7μM R03 exp135	2.67
Vemurafenib 6.6μM R02 exp89	3.15

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution