C8B
Gene Information
- Official Symbol: C8B
- Official Name: complement C8 beta chain
- Aliases and Previous Symbols: N/A
- Entrez ID: 732
- UniProt: P07358
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which mediates cell lysis, and it initiates membrane penetration of the complex. This protein mediates the interaction of C8 with the C5b-7 membrane attack complex precursor. In humans deficiency of this protein is associated with increased risk of meningococcal infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013].
- UniProt Summary: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 14333
- Expression level (log2 read counts): -7.68
C8B Expression in NALM6 Cells: -7.68
