CASP3
Gene Information
- Official Symbol: CASP3
- Official Name: caspase 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 836
- UniProt: P42574
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. {ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:7596430}.
Pfam Domains GO Terms
Pfam Domains
| Peptidase C14 |
GO Terms
| intrinsic apoptotic signaling pathway in response to osmotic stress |
| phospholipase A2 activator activity |
| anterior neural tube closure |
| cysteine-type endopeptidase activity involved in execution phase of apoptosis |
| cellular response to staurosporine |
| response to staurosporine |
| glial cell apoptotic process |
| death-inducing signaling complex |
| luteolysis |
| cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| response to cobalt ion |
| negative regulation of activated T cell proliferation |
| cyclin-dependent protein serine/threonine kinase inhibitor activity |
| positive regulation of amyloid-beta formation |
| death receptor binding |
| cysteine-type endopeptidase activity involved in apoptotic process |
| apoptotic DNA fragmentation |
| negative regulation of B cell proliferation |
| platelet formation |
| positive regulation of amyloid precursor protein catabolic process |
| platelet morphogenesis |
| neurotrophin TRK receptor signaling pathway |
| aspartic-type endopeptidase activity |
| axonal fasciculation |
| neuron projection fasciculation |
| DNA catabolic process, endonucleolytic |
| leukocyte apoptotic process |
| B cell homeostasis |
| apoptotic nuclear changes |
| hippo signaling |
| cellular component disassembly involved in execution phase of apoptosis |
| regulation of amyloid-beta formation |
| neurotrophin signaling pathway |
| response to X-ray |
| DNA catabolic process |
| negative regulation of cyclin-dependent protein serine/threonine kinase activity |
| negative regulation of cyclin-dependent protein kinase activity |
| negative regulation of B cell activation |
| extrinsic apoptotic signaling pathway in absence of ligand |
| signal transduction in absence of ligand |
| T cell homeostasis |
| regulation of amyloid precursor protein catabolic process |
| cellular response to alkaloid |
| cellular response to osmotic stress |
| regulation of activated T cell proliferation |
| ovulation cycle process |
| neuron apoptotic process |
| neuron recognition |
| response to nicotine |
| neuron death |
| execution phase of apoptosis |
| lymphocyte homeostasis |
| positive regulation of neuron apoptotic process |
| negative regulation of T cell proliferation |
| regulation of B cell proliferation |
| ovulation cycle |
| leukocyte homeostasis |
| negative regulation of mononuclear cell proliferation |
| negative regulation of lymphocyte proliferation |
| response to osmotic stress |
| negative regulation of leukocyte proliferation |
| erythrocyte differentiation |
| hippocampus development |
| peptidase activity |
| female gonad development |
| erythrocyte homeostasis |
| neural tube closure |
| tube closure |
| positive regulation of neuron death |
| cysteine-type endopeptidase activity |
| development of primary female sexual characteristics |
| extrinsic apoptotic signaling pathway |
| primary neural tube formation |
| regulation of cyclin-dependent protein serine/threonine kinase activity |
| protease binding |
| regulation of cyclin-dependent protein kinase activity |
| neural tube formation |
| female sex differentiation |
| myeloid cell homeostasis |
| limbic system development |
| negative regulation of T cell activation |
| response to alkaloid |
| response to amino acid |
| response to hydrogen peroxide |
| negative regulation of leukocyte cell-cell adhesion |
| embryonic epithelial tube formation |
| cellular response to ammonium ion |
| epithelial tube formation |
| negative regulation of protein serine/threonine kinase activity |
| response to estradiol |
| response to glucose |
| response to UV |
| response to hexose |
| morphogenesis of embryonic epithelium |
| negative regulation of lymphocyte activation |
| response to glucocorticoid |
| sensory perception of sound |
| tube formation |
| response to ionizing radiation |
| intrinsic apoptotic signaling pathway |
| response to monosaccharide |
| positive regulation of cellular amide metabolic process |
| regulation of T cell proliferation |
| protein processing |
| neural tube development |
| response to corticosteroid |
| sensory perception of mechanical stimulus |
| response to carbohydrate |
| regulation of macroautophagy |
| pallium development |
| negative regulation of leukocyte activation |
| negative regulation of cell-cell adhesion |
| response to ammonium ion |
| response to reactive oxygen species |
| negative regulation of cell activation |
| homeostasis of number of cells |
| striated muscle cell differentiation |
| regulation of neuron apoptotic process |
| regulation of B cell activation |
| regulation of lymphocyte proliferation |
| gonad development |
| regulation of mononuclear cell proliferation |
| development of primary sexual characteristics |
| myeloid cell differentiation |
| regulation of leukocyte proliferation |
| protein maturation |
| membrane raft |
| negative regulation of protein kinase activity |
| cell recognition |
| muscle cell differentiation |
| cell fate commitment |
| negative regulation of kinase activity |
| telencephalon development |
| learning or memory |
| response to tumor necrosis factor |
| sex differentiation |
| protein-containing complex binding |
| negative regulation of cell adhesion |
| keratinocyte differentiation |
| rhythmic process |
| negative regulation of transferase activity |
| apoptotic signaling pathway |
| regulation of protein stability |
| regulation of leukocyte cell-cell adhesion |
| nucleic acid phosphodiester bond hydrolysis |
| cognition |
| response to antibiotic |
| response to light stimulus |
| epithelial tube morphogenesis |
| regulation of neuron death |
| response to lipopolysaccharide |
| cellular response to environmental stimulus |
| cellular response to abiotic stimulus |
| epidermal cell differentiation |
| regulation of T cell activation |
| response to molecule of bacterial origin |
| response to steroid hormone |
| regulation of autophagy |
| response to hypoxia |
| response to acid chemical |
| response to decreased oxygen levels |
| response to metal ion |
| neuronal cell body |
| nucleobase-containing compound catabolic process |
| response to oxygen levels |
| skin development |
| forebrain development |
| response to oxidative stress |
| regulation of cell-cell adhesion |
| cellular component disassembly |
| regulation of cellular amide metabolic process |
| negative regulation of protein phosphorylation |
| axon development |
| epidermis development |
| reproductive structure development |
| reproductive system development |
| morphogenesis of an epithelium |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| response to radiation |
| negative regulation of immune system process |
| aromatic compound catabolic process |
| negative regulation of phosphorylation |
| muscle structure development |
| wound healing |
| organic cyclic compound catabolic process |
| cellular response to growth factor stimulus |
| response to toxic substance |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| regulation of lymphocyte activation |
| regulation of protein serine/threonine kinase activity |
| heart development |
| response to growth factor |
| response to inorganic substance |
| cellular response to organic cyclic compound |
| hemopoiesis |
| cell morphogenesis involved in differentiation |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| tissue morphogenesis |
| embryonic morphogenesis |
| response to wounding |
| behavior |
| negative regulation of cell cycle |
| negative regulation of protein modification process |
| cellular response to organonitrogen compound |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| chordate embryonic development |
| regulation of cell activation |
| positive regulation of apoptotic process |
| immune system development |
| positive regulation of programmed cell death |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| cellular response to nitrogen compound |
| neuron projection development |
| developmental process involved in reproduction |
| cytokine-mediated signaling pathway |
| negative regulation of cell population proliferation |
| epithelial cell differentiation |
| regulation of cell adhesion |
| response to bacterium |
| positive regulation of cell death |
| enzyme linked receptor protein signaling pathway |
| cell morphogenesis |
| brain development |
| DNA metabolic process |
| cellular response to DNA damage stimulus |
| head development |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| neuron development |
| cellular component morphogenesis |
| multicellular organismal reproductive process |
| regulation of cellular catabolic process |
| multicellular organism reproduction |
| tube development |
| response to lipid |
| circulatory system development |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| cellular macromolecule catabolic process |
| negative regulation of programmed cell death |
| response to hormone |
| response to organic cyclic compound |
| apoptotic process |
| sensory perception |
| regulation of transferase activity |
| embryo development |
| central nervous system development |
| negative regulation of cell death |
| regulation of catabolic process |
| response to organonitrogen compound |
| cellular response to cytokine stimulus |
| neuron differentiation |
| response to drug |
| negative regulation of cellular protein metabolic process |
| macromolecule catabolic process |
| programmed cell death |
| response to nitrogen compound |
| cell death |
| response to cytokine |
| negative regulation of protein metabolic process |
| epithelium development |
| plasma membrane bounded cell projection organization |
| negative regulation of molecular function |
| response to abiotic stimulus |
| cell projection organization |
| regulation of cell cycle |
| cellular response to endogenous stimulus |
| proteolysis |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| nervous system process |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| generation of neurons |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| regulation of cell population proliferation |
| neurogenesis |
| homeostatic process |
| cell development |
| regulation of immune system process |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| tissue development |
| organic substance catabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| regulation of protein modification process |
| system process |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17662
- Expression level (log2 read counts): 5.65
Expression Distribution
CASP3 Expression in NALM6 Cells: 5.65
