Pfam Domains GO Terms
| Cpn60 TCP1 |
| WD40-repeat domain binding |
| positive regulation of protein localization to Cajal body |
| regulation of protein localization to Cajal body |
| positive regulation of establishment of protein localization to telomere |
| chaperonin-containing T-complex |
| regulation of establishment of protein localization to telomere |
| positive regulation of protein localization to chromosome, telomeric region |
| regulation of establishment of protein localization to chromosome |
| regulation of protein localization to chromosome, telomeric region |
| positive regulation of telomerase RNA localization to Cajal body |
| regulation of telomerase RNA localization to Cajal body |
| positive regulation of telomere maintenance via telomerase |
| positive regulation of telomere maintenance via telomere lengthening |
| positive regulation of telomere maintenance |
| regulation of telomere maintenance via telomerase |
| regulation of telomere maintenance via telomere lengthening |
| positive regulation of DNA biosynthetic process |
| positive regulation of protein localization to nucleus |
| regulation of telomere maintenance |
| regulation of DNA biosynthetic process |
| regulation of protein localization to nucleus |
| unfolded protein binding |
| positive regulation of chromosome organization |
| protein stabilization |
| positive regulation of DNA metabolic process |
| protein folding |
| regulation of protein stability |
| microtubule |
| positive regulation of cellular protein localization |
| regulation of chromosome organization |
| regulation of DNA metabolic process |
| positive regulation of establishment of protein localization |
| regulation of cellular protein localization |
| positive regulation of organelle organization |
| regulation of establishment of protein localization |
| regulation of cellular localization |
| regulation of protein localization |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| RNA binding |
| ATP binding |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| Lapatinib 5μM R01 exp47 | -2.25 |
| 39°C R06 exp303 | -2.23 |
| A-395 10μM R05 exp218 | -2 |
| QNZ 0.01μM R05 exp241 | -2 |
| Pomalidomide 20μM R07 exp391 | -1.78 |
| Deguelin 0.15μM R05 exp209 | -1.77 |
| UNC1999 2μM R03 exp155 | -1.74 |
| Etoposide 1μM R00 exp19 | 1.73 |
| Nocodazole 0.2μM R00 exp24 | 1.74 |
| Rotenone 20μM R00 exp34 | 1.95 |
| Etoposide 10μM R00 exp20 | 2.09 |
| Actinomycin-D 0.01μM R00 exp4 | 2.78 |
| Gene | Correlation |
|---|---|
| HARS | 0.571 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 0/1 |
| bile duct | 11/28 |
| blood | 15/28 |
| bone | 7/26 |
| breast | 15/33 |
| central nervous system | 26/56 |
| cervix | 2/4 |
| colorectal | 7/17 |
| esophagus | 3/13 |
| fibroblast | 1/1 |
| gastric | 5/16 |
| kidney | 6/21 |
| liver | 6/20 |
| lung | 18/75 |
| lymphocyte | 8/16 |
| ovary | 8/26 |
| pancreas | 4/24 |
| peripheral nervous system | 6/16 |
| plasma cell | 6/15 |
| prostate | 1/1 |
| skin | 5/24 |
| soft tissue | 4/9 |
| thyroid | 1/2 |
| upper aerodigestive | 4/22 |
| urinary tract | 6/29 |
| uterus | 2/5 |
Expression Distribution