Pfam Domains GO Terms
| Pkinase |
| Pkinase Tyr |
| positive regulation of nuclear cell cycle DNA replication |
| double-strand break repair via break-induced replication |
| positive regulation of DNA-dependent DNA replication |
| regulation of nuclear cell cycle DNA replication |
| positive regulation of G2/M transition of mitotic cell cycle |
| positive regulation of cell cycle G2/M phase transition |
| positive regulation of DNA replication |
| negative regulation of G0 to G1 transition |
| regulation of G0 to G1 transition |
| regulation of DNA-dependent DNA replication |
| intercellular bridge |
| positive regulation of mitotic cell cycle phase transition |
| mitotic spindle |
| kinase activity |
| peptidyl-threonine phosphorylation |
| peptidyl-threonine modification |
| positive regulation of cell cycle phase transition |
| double-strand break repair via homologous recombination |
| recombinational repair |
| regulation of DNA replication |
| G1/S transition of mitotic cell cycle |
| cell cycle G1/S phase transition |
| positive regulation of mitotic cell cycle |
| peptidyl-serine phosphorylation |
| double-strand break repair |
| regulation of G2/M transition of mitotic cell cycle |
| peptidyl-serine modification |
| regulation of cell cycle G2/M phase transition |
| DNA replication |
| DNA recombination |
| protein kinase activity |
| mitotic cell cycle phase transition |
| cell cycle phase transition |
| positive regulation of cell cycle process |
| negative regulation of cell cycle process |
| protein serine/threonine kinase activity |
| positive regulation of cell cycle |
| regulation of mitotic cell cycle phase transition |
| regulation of cell cycle phase transition |
| cell division |
| DNA repair |
| negative regulation of cell cycle |
| mitotic cell cycle process |
| regulation of mitotic cell cycle |
| mitotic cell cycle |
| DNA metabolic process |
| regulation of cell cycle process |
| cellular response to DNA damage stimulus |
| peptidyl-amino acid modification |
| positive regulation of cell population proliferation |
| protein phosphorylation |
| cell cycle process |
| regulation of cell cycle |
| phosphorylation |
| cell cycle |
| ATP binding |
| regulation of cell population proliferation |
| cellular response to stress |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| R-DABN 8μM R03 exp111 | -1.95 |
| Epothilone-B 0.0015μM R05 exp231 | 1.72 |
| Colchicine 0.009μM R05 exp215 | 1.77 |
| Daidzin 10μM R06 exp280 | 1.85 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 26/28 |
| blood | 27/28 |
| bone | 25/26 |
| breast | 33/33 |
| central nervous system | 55/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 20/21 |
| liver | 20/20 |
| lung | 74/75 |
| lymphocyte | 16/16 |
| ovary | 26/26 |
| pancreas | 24/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 20/22 |
| urinary tract | 29/29 |
| uterus | 5/5 |
Expression Distribution