CEP76

Entrez Summary: N/A
UniProt Summary: Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication. {ECO:0000269|PubMed:19460342}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
A-769662 20μM R07 exp331	-2.21
LY2090314 0.003μM R08 exp499	-2.2
Amiloride 100μM R08 exp447	-1.91
Nicotinamide Riboside 100μM R03 exp139	-1.86
GSK-J4 1μM R07 exp362	-1.82
NFN1 1μM R03 exp100	-1.73
Genistein 15μM R07 exp360	2.11
DABN 2μM R00 exp16	2.63
RO-3307 4.7μM R02 exp80	2.8
Cytochalasin-B 5μM R07 exp349	4.65
Latrunculin-B 10μM R07 exp374	5.7
Tozasertib 0.1μM R07 exp414	5.94

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution