CRYBA2
Gene Information
- Official Symbol: CRYBA2
- Official Name: crystallin beta A2
- Aliases and Previous Symbols: N/A
- Entrez ID: 1412
- UniProt: P53672
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of the vertebrate eye, which function to maintain the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also defined as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group but absent in the acidic group). Beta-crystallins form aggregates of different sizes and are able to form homodimers through self-association or heterodimers with other beta-crystallins. This gene is a beta acidic group member. Three alternatively spliced transcript variants encoding identical proteins have been reported. [provided by RefSeq, Jul 2008].
- UniProt Summary: Crystallins are the dominant structural components of the vertebrate eye lens.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 17923
- Expression level (log2 read counts): -6.6
CRYBA2 Expression in NALM6 Cells: -6.6
