DENR
Gene Information
- Official Symbol: DENR
- Official Name: density regulated re-initiation and release factor
- Aliases and Previous Symbols: N/A
- Entrez ID: 8562
- UniProt: O43583
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1. {ECO:0000269|PubMed:16982740, ECO:0000269|PubMed:17878526, ECO:0000269|PubMed:20713520}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 3999
- Expression level (log2 read counts): 6.59
DENR Expression in NALM6 Cells: 6.59
