DRC1
Gene Information
- Official Symbol: DRC1
- Official Name: dynein regulatory complex subunit 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 92749
- UniProt: Q96MC2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a central component of the nexin-dynein complex (N-DRC), which regulates the assembly of ciliary dynein. Mutations in this gene can cause ciliary dyskinesia. [provided by RefSeq, Aug 2015].
- UniProt Summary: Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending. {ECO:0000269|PubMed:23354437}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 18416
- Expression level (log2 read counts): -4.6
DRC1 Expression in NALM6 Cells: -4.6
