EIF2S1
Gene Information
- Official Symbol: EIF2S1
- Official Name: eukaryotic translation initiation factor 2 subunit alpha
- Aliases and Previous Symbols: N/A
- Entrez ID: 1965
- UniProt: P05198
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2- GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
Pfam Domains GO Terms
Pfam Domains
| EIF 2 alpha |
| S1 |
GO Terms
| translation initiation ternary complex |
| multi-eIF complex |
| positive regulation of type B pancreatic cell apoptotic process |
| response to manganese-induced endoplasmic reticulum stress |
| glial limiting end-foot |
| negative regulation of translational initiation in response to stress |
| negative regulation of guanyl-nucleotide exchange factor activity |
| eukaryotic translation initiation factor 2 complex |
| eukaryotic translation initiation factor 2B complex |
| negative regulation of translation in response to stress |
| regulation of guanyl-nucleotide exchange factor activity |
| regulation of type B pancreatic cell apoptotic process |
| regulation of translational initiation in response to stress |
| cellular response to manganese ion |
| PERK-mediated unfolded protein response |
| regulation of GTP binding |
| eukaryotic 48S preinitiation complex |
| regulation of translation in response to stress |
| stress granule assembly |
| negative regulation of translational initiation |
| response to manganese ion |
| positive regulation of epithelial cell apoptotic process |
| ER-nucleus signaling pathway |
| cellular response to amino acid starvation |
| polysome |
| response to amino acid starvation |
| translation initiation factor activity |
| ribosome binding |
| cytoplasmic stress granule |
| cellular response to heat |
| regulation of translational initiation |
| regulation of epithelial cell apoptotic process |
| cellular response to UV |
| positive regulation of neuron death |
| negative regulation of protein binding |
| endoplasmic reticulum unfolded protein response |
| response to heat |
| cellular response to light stimulus |
| cellular response to unfolded protein |
| negative regulation of translation |
| response to UV |
| translational initiation |
| negative regulation of cellular amide metabolic process |
| cellular response to topologically incorrect protein |
| cellular response to starvation |
| response to unfolded protein |
| negative regulation of binding |
| cellular response to radiation |
| response to temperature stimulus |
| positive regulation of binding |
| response to topologically incorrect protein |
| cellular response to metal ion |
| response to starvation |
| protein autophosphorylation |
| regulation of protein binding |
| cellular response to inorganic substance |
| ribonucleoprotein complex assembly |
| cellular response to nutrient levels |
| cellular response to oxidative stress |
| ribonucleoprotein complex subunit organization |
| response to endoplasmic reticulum stress |
| cellular response to extracellular stimulus |
| synapse |
| aging |
| response to light stimulus |
| regulation of neuron death |
| cellular response to environmental stimulus |
| cellular response to abiotic stimulus |
| cellular response to external stimulus |
| regulation of translation |
| response to metal ion |
| regulation of binding |
| translation |
| response to oxidative stress |
| regulation of cellular amide metabolic process |
| peptide biosynthetic process |
| response to radiation |
| ribonucleoprotein complex biogenesis |
| response to nutrient levels |
| posttranscriptional regulation of gene expression |
| amide biosynthetic process |
| peptide metabolic process |
| response to extracellular stimulus |
| response to inorganic substance |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| positive regulation of cell death |
| organelle assembly |
| cellular amide metabolic process |
| cellular protein-containing complex assembly |
| protein phosphorylation |
| negative regulation of cellular protein metabolic process |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| response to abiotic stimulus |
| transmembrane transport |
| phosphorylation |
| negative regulation of cellular macromolecule biosynthetic process |
| RNA binding |
| organonitrogen compound biosynthetic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| protein-containing complex assembly |
| regulation of programmed cell death |
| cellular nitrogen compound biosynthetic process |
| regulation of cell death |
| cellular response to stress |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| protein-containing complex subunit organization |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 739/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 28/28 |
| bone | 26/26 |
| breast | 33/33 |
| central nervous system | 56/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 21/21 |
| liver | 20/20 |
| lung | 75/75 |
| lymphocyte | 16/16 |
| ovary | 26/26 |
| pancreas | 24/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 29/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 292
- Expression level (log2 read counts): 7.05
Expression Distribution
EIF2S1 Expression in NALM6 Cells: 7.05
