EPC1
Gene Information
- Official Symbol: EPC1
- Official Name: enhancer of polycomb homolog 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 80314
- UniProt: Q9H2F5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| E Pc C |
| EPL1 |
GO Terms
| Piccolo NuA4 histone acetyltransferase complex |
| vascular smooth muscle cell differentiation |
| histone H2A acetylation |
| NuA4 histone acetyltransferase complex |
| smooth muscle cell differentiation |
| negative regulation of G0 to G1 transition |
| regulation of G0 to G1 transition |
| histone acetyltransferase activity |
| histone H4 acetylation |
| negative regulation of gene expression, epigenetic |
| histone acetylation |
| internal peptidyl-lysine acetylation |
| peptidyl-lysine acetylation |
| internal protein amino acid acetylation |
| protein acetylation |
| protein acylation |
| regulation of gene expression, epigenetic |
| nuclear membrane |
| muscle cell differentiation |
| peptidyl-lysine modification |
| negative regulation of cell cycle process |
| histone modification |
| covalent chromatin modification |
| muscle structure development |
| vasculature development |
| cardiovascular system development |
| negative regulation of cell cycle |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| regulation of growth |
| chromatin organization |
| regulation of cell cycle process |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| peptidyl-amino acid modification |
| chromosome organization |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| EPC2 | 0.479 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 8/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 1/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 1/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 1/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 2/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2941
- Expression level (log2 read counts): 6.17
Expression Distribution
EPC1 Expression in NALM6 Cells: 6.17
