FAF1
Gene Information
- Official Symbol: FAF1
- Official Name: Fas associated factor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 11124
- UniProt: Q9UNN5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Potentiates but cannot initiate FAS-induced apoptosis.
Pfam Domains GO Terms
Pfam Domains
| UBX |
GO Terms
| CD95 death-inducing signaling complex |
| cytoplasmic sequestering of NF-kappaB |
| VCP-NPL4-UFD1 AAA ATPase complex |
| protein kinase regulator activity |
| positive regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| cytoplasmic sequestering of transcription factor |
| cytoplasmic sequestering of protein |
| NF-kappaB binding |
| positive regulation of DNA replication |
| positive regulation of extrinsic apoptotic signaling pathway |
| regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| heat shock protein binding |
| ubiquitin binding |
| negative regulation of NF-kappaB transcription factor activity |
| maintenance of protein location |
| regulation of DNA replication |
| positive regulation of cellular protein catabolic process |
| regulation of extrinsic apoptotic signaling pathway |
| negative regulation of DNA-binding transcription factor activity |
| maintenance of location |
| positive regulation of apoptotic signaling pathway |
| nuclear envelope |
| positive regulation of protein catabolic process |
| protein domain specific binding |
| regulation of cellular protein catabolic process |
| positive regulation of protein complex assembly |
| ubiquitin protein ligase binding |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| proteasomal protein catabolic process |
| positive regulation of cellular catabolic process |
| regulation of protein catabolic process |
| regulation of apoptotic signaling pathway |
| regulation of DNA-binding transcription factor activity |
| positive regulation of catabolic process |
| regulation of protein complex assembly |
| protein kinase binding |
| positive regulation of cellular component biogenesis |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| proteolysis involved in cellular protein catabolic process |
| cellular protein catabolic process |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| regulation of cell adhesion |
| protein catabolic process |
| perinuclear region of cytoplasm |
| positive regulation of cell death |
| regulation of protein kinase activity |
| regulation of cellular catabolic process |
| regulation of kinase activity |
| cellular macromolecule catabolic process |
| apoptotic process |
| regulation of cellular component biogenesis |
| regulation of transferase activity |
| regulation of catabolic process |
| macromolecule catabolic process |
| programmed cell death |
| organonitrogen compound catabolic process |
| cell death |
| negative regulation of molecular function |
| positive regulation of cellular component organization |
| proteolysis |
| regulation of protein phosphorylation |
| regulation of apoptotic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| organic substance catabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of protein modification process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.641 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3082
- Expression level (log2 read counts): 6.17
Expression Distribution
FAF1 Expression in NALM6 Cells: 6.17
