FBXL20
Gene Information
- Official Symbol: FBXL20
- Official Name: F-box and leucine rich repeat protein 20
- Aliases and Previous Symbols: N/A
- Entrez ID: 84961
- UniProt: Q96IG2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| F-box |
| F-box-like |
GO Terms
| regulation of protein catabolic process at presynapse, modulating synaptic transmission |
| presynaptic modulation of chemical synaptic transmission |
| behavioral fear response |
| behavioral defense response |
| fear response |
| SCF ubiquitin ligase complex |
| multicellular organismal response to stress |
| regulation of synaptic vesicle exocytosis |
| Schaffer collateral - CA1 synapse |
| SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| presynapse |
| regulation of neurotransmitter secretion |
| regulation of synaptic vesicle cycle |
| regulation of neurotransmitter transport |
| regulation of regulated secretory pathway |
| regulation of exocytosis |
| ubiquitin-protein transferase activity |
| protein polyubiquitination |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| glutamatergic synapse |
| proteasomal protein catabolic process |
| regulation of neurotransmitter levels |
| post-translational protein modification |
| regulation of protein catabolic process |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| regulation of vesicle-mediated transport |
| behavior |
| proteolysis involved in cellular protein catabolic process |
| cellular protein catabolic process |
| protein catabolic process |
| protein ubiquitination |
| regulation of secretion by cell |
| protein modification by small protein conjugation |
| regulation of secretion |
| cellular macromolecule catabolic process |
| regulation of cellular localization |
| protein modification by small protein conjugation or removal |
| regulation of catabolic process |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| proteolysis |
| defense response |
| organic substance catabolic process |
| cellular catabolic process |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14307
- Expression level (log2 read counts): 5.36
Expression Distribution
FBXL20 Expression in NALM6 Cells: 5.36
