FBXL5

Entrez Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Docosahexaenoic-acid 50μM R07 exp356	-3.05
Citral 75μM R06 exp275	-1.98
Thimerosal 0.85μM R08 exp529	-1.83
Trimetrexate 0.03μM R08 exp535	-1.79
QNZ 0.01μM R05 exp241	1.76
Rifampicin 10μM R00 exp32	1.79
Latrunculin-B 10μM R07 exp374	1.85
Hydroxyurea 100μM R07 exp329	1.87
CoCl2 18μM R07 exp346	1.89
DABN 20μM R00 exp17	1.9
Deguelin 0.15μM R05 exp209	1.97
Phenformin 20μM R05 exp212	2.03
Dimethyloxaloylglycine 100μM R05 exp229	3.5

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution