GGPS1
Gene Information
- Official Symbol: GGPS1
- Official Name: geranylgeranyl diphosphate synthase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 9453
- UniProt: O95749
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.
Pfam Domains GO Terms
Pfam Domains
| polyprenyl synt |
GO Terms
| geranylgeranyl diphosphate metabolic process |
| geranylgeranyl diphosphate biosynthetic process |
| dimethylallyltranstransferase activity |
| farnesyltranstransferase activity |
| geranyl diphosphate biosynthetic process |
| geranyl diphosphate metabolic process |
| geranyltranstransferase activity |
| farnesyl diphosphate biosynthetic process |
| farnesyl diphosphate metabolic process |
| terpenoid biosynthetic process |
| isoprenoid biosynthetic process |
| cholesterol biosynthetic process |
| regulation of sterol biosynthetic process |
| secondary alcohol biosynthetic process |
| regulation of cholesterol biosynthetic process |
| sterol biosynthetic process |
| regulation of cholesterol metabolic process |
| regulation of alcohol biosynthetic process |
| regulation of steroid biosynthetic process |
| alcohol biosynthetic process |
| regulation of steroid metabolic process |
| cholesterol metabolic process |
| terpenoid metabolic process |
| steroid biosynthetic process |
| secondary alcohol metabolic process |
| sterol metabolic process |
| isoprenoid metabolic process |
| organic hydroxy compound biosynthetic process |
| regulation of lipid biosynthetic process |
| phospholipid biosynthetic process |
| steroid metabolic process |
| alcohol metabolic process |
| phospholipid metabolic process |
| regulation of lipid metabolic process |
| regulation of small molecule metabolic process |
| organic hydroxy compound metabolic process |
| organophosphate biosynthetic process |
| lipid biosynthetic process |
| small molecule biosynthetic process |
| organophosphate metabolic process |
| cellular lipid metabolic process |
| identical protein binding |
| lipid metabolic process |
| organic cyclic compound biosynthetic process |
| small molecule metabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 681/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 27/28 |
| blood | 26/28 |
| bone | 25/26 |
| breast | 22/33 |
| central nervous system | 56/56 |
| cervix | 4/4 |
| colorectal | 16/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 15/16 |
| kidney | 19/21 |
| liver | 19/20 |
| lung | 67/75 |
| lymphocyte | 13/16 |
| ovary | 22/26 |
| pancreas | 24/24 |
| peripheral nervous system | 14/16 |
| plasma cell | 13/15 |
| prostate | 1/1 |
| skin | 20/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 28/29 |
| uterus | 3/5 |
Essentiality in NALM6
- Essentiality Rank: 979
- Expression level (log2 read counts): 4.24
Expression Distribution
GGPS1 Expression in NALM6 Cells: 4.24
