Entrez Summary: This gene encodes a subunit of the augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis. The encoded protein was identified by interaction with ubiquitin C-terminal hydrolase 37. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012].
UniProt Summary: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}.
Pfam DomainsGO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
HAUS complex
thioesterase binding
microtubule minus-end binding
centrosome cycle
microtubule organizing center organization
ciliary basal body-plasma membrane docking
spindle assembly
spindle
G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
spindle organization
organelle localization by membrane tethering
membrane docking
regulation of G2/M transition of mitotic cell cycle